Name & Type

Fmoc-Tyr(SO3Na)-OH

in Pharmaceutical Intermediates, Type: sell

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  • Fmoc-Tyr(SO3Na)-OH
  • HONG KONG PE BIOSCIENCES LIMITED is a manufacturer and exporter of highly qualified amino acids derivatives, peptides, proteins and enabling technologies for scientific research. Our comprehensive products consist […]

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 Country Of Origin: China
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Description

Product name: Fmoc-Tyr(SO3Na)-OH

Catalog #: 8127001

Purity: 95% by HPLC

CAS No.: 181952-24-9

Molecular Formula: C24H21NO8S

Molecular Weight: 483.5

Description:

Tyrosine sulfation is one of the most common post-translational modifications in secreted and transmembrane proteins and a key modulator of extracellular protein-protein interactions. The desulfation obeyed first-order kinetics with a large entropy (59.6 J.K-1.mol-1) and enthalpy (110.5 kJ.mol-1) of activation. These values substantiated that the desulfation rate of the rigidly solvated Tyr(SO3H) residue was strongly temperature-dependent. The synthetic strategy for Tyr(SO3H)-containing peptides with this effective deprotection protocol is as follows: (i) a sulfated peptide chain is directly constructed on 2-chlorotrityl resin with Fmoc-based solid-phase chemistry using Fmoc-Tyr(SO3Na)-OH as a building block; (ii) the protected peptide-resin is treated with 90% aqueous TFA at 0 degree C for an appropriate period of time for the cleavage and deprotection.

 

Usage: For Scientific Research Use Only, Not for Human Use.

 

Reference:

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Volume 161, Issue 4, April 2012, Pages 372-378.

N Biotechnol. 2009 Jun;25(5):299-317.

Biopolymers. 2008;90(3):459-77.

Biochemical and Biophysical Research Communications, Volume 298, Issue 2, 25 October 2002, Pages 193-197.

Bioorganic & Medicinal Chemistry, Volume 9, Issue 2, February 2001, Pages 487-492.

Biochemical and Biophysical Research Communications, Volume 262, Issue 1, 19 August 1999, Pages 193-197.

 

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