Product name: Fmoc-Thr(tBu)-ol
Synonym: (9H-Fluoren-9-yl)methyl ((2R,3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate, (2R,3R)-2-(Fmoc-amino)-3-tert-butoxy-1-butanol, Fmoc-Threoninol(tBu),
Catalog #: 8132091
Purity: 95% by HPLC
CAS No.: 189337-28-8
Molecular Formula: C23H29NO4
Molecular Weight: 383.48
Compound ID: 11143467
Description: Fmoc-Thr(tBu)-ol, prepared from Fmoc-Thr(tBu)-OH, was loaded onto 2-chlorotrityl chloride resin. After construction of the peptide chains by Fmoc chemistry, mDTPA was coupled to the alpha amine group of the peptide on the resin in the presence of 1,3-diisopropylcarbodiimide and 1-hydroxybenzotriazole. Treatment of the mDTPA-peptide-resin with trifluoroacetic acid-thioanisole removed the protecting groups and liberated [Cys(Acm)2,7]-octreotide-D-Phe1-DTPA from the resin. Iodine oxidation of the DTPA-peptide, followed by the reversed-phase HPLC purification, produced DTPA-D-Phe1-octreotide in overall 31.8% yield based on the starting Fmoc-Thr(tBu)-ol-resin.
Usage: For Scientific Research Use Only, Not for Human Use.
Bioconjug Chem. 1997 May-Jun,8(3):442-6.