Name & Type

Fmoc-Thr(tBu)-ol

in Pharmaceutical Intermediates, Type: sell

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  • Fmoc-Thr(tBu)-ol
  • HONG KONG PE BIOSCIENCES LIMITED is a manufacturer and exporter of highly qualified amino acids derivatives, peptides, proteins and enabling technologies for scientific research. Our comprehensive products consist […]

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 Country Of Origin: China
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Description

Product name: Fmoc-Thr(tBu)-ol

Synonym: (9H-Fluoren-9-yl)methyl ((2R,3R)-3-(tert-butoxy)-1-hydroxybutan-2-yl)carbamate, (2R,3R)-2-(Fmoc-amino)-3-tert-butoxy-1-butanol, Fmoc-Threoninol(tBu),

Catalog #: 8132091

Purity: 95% by HPLC

CAS No.: 189337-28-8

Molecular Formula: C23H29NO4

Molecular Weight: 383.48

Compound ID: 11143467

Description: Fmoc-Thr(tBu)-ol, prepared from Fmoc-Thr(tBu)-OH, was loaded onto 2-chlorotrityl chloride resin. After construction of the peptide chains by Fmoc chemistry, mDTPA was coupled to the alpha amine group of the peptide on the resin in the presence of 1,3-diisopropylcarbodiimide and 1-hydroxybenzotriazole. Treatment of the mDTPA-peptide-resin with trifluoroacetic acid-thioanisole removed the protecting groups and liberated [Cys(Acm)2,7]-octreotide-D-Phe1-DTPA from the resin. Iodine oxidation of the DTPA-peptide, followed by the reversed-phase HPLC purification, produced DTPA-D-Phe1-octreotide in overall 31.8% yield based on the starting Fmoc-Thr(tBu)-ol-resin.

 

Usage: For Scientific Research Use Only, Not for Human Use.

 

Reference:

Bioconjug Chem. 1997 May-Jun,8(3):442-6.

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