Alias: DNP; 2,4- dinitrophenol
Relative molecular mass: 183.099
Melting point: 106-112 ° C
Melting point: 112 ~ 114 ºC
Toxicity: Inhalation, ingestion or skin contact with poison, and the accumulative damage storage method: Sealed in a cool dark place to preserve
DNP (2, 4-DNP, or simply DNP) is an organic compound with the formula HOC6H3(NO2)2. It is a yellow, crystalline solid that has a sweet, musty odor. It sublimes, is volatile with steam, and is soluble in most organic solvents as well as aqueous alkaline solutions.
DNP is a precursor to other chemicals and is biochemically active, inhibiting energy (ATP) production in cells with mitochondria and was once used as a diet aid.DNP is produced by hydrolysis of 2, 4-dinitrochlorobenzene.
DNP as a mechanism of action uncoupler is: DNP did not inhibit transfer of electrons, but it can eliminate the proton driving force required for the synthesis of ATP.
Since DNP is a lipophilic compound is weakly acidic, it passes through the neutral state proton mitochondrial inner membrane lipid bilayer. When there is a proton gradient across the membrane, it is incorporated in the acidic side of the membrane proton to become a neutral state uncharged, by diffusion through the membrane, and in the alkaline side of the membrane to release a proton, thereby neutralized cross membrane proton gradient.