Name & Type

Aicar CAS 2627-69-2 Cardiovascular Diseases Treatment Acadesine

in Antibiotic and Antimicrobial Agents, Type: sell

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  • Aicar CAS 2627-69-2 Cardiovascular Diseases Treatment Acadesine
  • Saler at Wuhan Hezhong Biochemic...
    China
  • Our main products include steroid powder ,pharmaceutical raw materialand and peptides , which are widely used in health products for bodybuliding,muscle,weight loss and so forth.The Testosterone series,Tren A,Tren […]

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 Country Of Origin: China
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Description

AICAR
Aicar CAS 2627-69-2 Cardiovascular Diseases Treatment Acadesine
Quick Detail:
Acadesine
Alias: AICAR; AICA-RIBOSIDE; AMPK; Z-RIBOSIDE
CAS: 2627-69-2
EINECS: 220-097-5
Molecular Formula: C9H14N4O5
Molecular Weight: 258.23
Assay: 98%
Apperance: White or off-white powder.
Usage: Pharmaceutical intermediates. For the treatment of cardiovascular diseases

Functions:
AICAR (AICA-Riboside) strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

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